Molecular Drug Targeting

We focus on the development of small molecule ligands for targeted delivery purposes. For this, protein-ligand interactions are investigated using biophysical and computational techniques, as well as cell-based methods. Major targets of our research are glycan-binding proteins, such as C-type lectin receptors since they often represent unique markers for cell subsets. 
In particular, we explore the potential of targeted delivery to Langerhans cells, immune cells residing in the epidermis, harnessing their potential for the development of novel transdermal vaccines.

Please follow these links for more details on:

• Structure and Function of C-type Lectin Receptors
• Targeted Delivery to Langerhans cells
• Glycan-based Cell-Cell Communication
• Small Molecular Modulators of C-type Lectin Receptors
• Inhibitors of Bacterial Lectins
• Allostery in Drug Discovery